Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy

Painful Diabetic Neuropathy

N europathic pain exerts a substantial impact on quality of life, particularly by causing considerable interference in sleep, daily activities, and enjoyment of life. Chronic neuropathic pain is present in 13–26% of diabetic patients (1– 4). In a recent survey from Augsburg, Germany, the prevalence of painful polyneuropathy was found to be 13.3% in diabetic subjects, 8.7% in individuals with im...

Painful diabetic neuropathy.

PDN is commonly caused by involvement of either the C fibres or the Aδ fibres. PDN caused by the involvement of small nerve fibers (C fibres), may present without objective clinical findings, such as decreased peripheral reflexes or abnormalities, on routine electrophysiological studies. Small fiber neuropathies may manifest as a number of different clinical symptoms, including allodynia, burni...

Painful diabetic neuropathy pdf

Pathogenesis of Painful Diabetic Neuropathy

The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. It has a huge effect on a person's daily life, both physically and mentally. Despite huge advances in d...

Treatment of painful diabetic neuropathy.

P neuropathy is one of the commonest long term complications of diabetes mellitus which has been reported to be prevalent in 22% of d iabe t i c cohor t . 1 Pa in fu l d iabe t i c neuropathy (PDN) occurs in 6% of the patients with diabetic peripheral neuropathy (DPN) and this is most distressing symptom which impairs quality of life.2 Patients seek advice to get relief but unfortunately treatm...